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Interceptor® G2 – Breakthrough To Beat Insecticide Resistance

Interceptor® G2 is a long-lasting, insecticide-treated mosquito net that combats resistant mosquitoes. BASF has received a WHO PQ listing for the Interceptor® G2 net so that it may be used in the fight against malaria. This is the first malaria control product based on a new insecticide class for more than 30 years.

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Malaria is preventable and curable. Since 2010, nearly seven million lives, primarily young children, have been saved largely due to the distribution of insecticide- treated mosquito nets. However, growing resistance to public health insecticides could threaten the progress of recent years. Alternatives are urgently needed.

 

Now, after a collaboration with the Innovative Vector Control Consortium and the London School of Hygiene & Tropical Medicine that lasted more than a decade, BASF’s scientists have successfully repurposed chlorfenapyr – a completely new insecticide class for mosquito control in public health - to be effective on mosquito nets and meet the stringent WHO performance thresholds for public health.

 

The new net is based on a novel combination of chlorfenapyr and alpha-cypermethrin to both protect sleepers and combat resistant mosquitoes. It is now the first insecticide-treated mosquito net that is not only based on pyrethroid chemistry.

 

Following the WHO PQ listing, BASF started preparations to launch Interceptor® G2 for malaria control. Depending on local registration processes, the new mosquito net has been available to health ministries and aid organizations since 2018. A second chlorfenapyr product, an indoor residual spray named Sylando® 240SC to coat interior walls and ceilings, is under evaluation for WHO PQ listing.

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The story behind the development

"A new development that actually enables the malaria community to deal with resistant mosquitoes - the first new mode of action product since 30 years in this market"

 

The scientists and developers behind Interceptor® G2 talk about the challenges, the highs and lows, and what this breakthrough in malaria control means to them personally.

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Interceptor® G2 - Why is it so special?

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What is insecticide resistance?

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How challenging was it to develop?

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What does it mean to BASF and the people behind it?

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Interceptor® G2 – Proven In Independent Trials

Independent trials in Benin, Burkina Faso, Tanzania and Ivory Coast have proven the efficacy of BASF's new chlorfenapyr products against local insecticide-resistant mosquitoes. Field trial results from the Innovative Vector Control Consortium show that BASF’s innovative long-lasting mosquito net, Interceptor® G2, controls insecticide-resistant mosquitoes effectively. The development marks a significant scientific breakthrough that can meet the challenge of malaria control in areas where conventional nets are failing due to resistance.

Interceptor® G2 is the first long-lasting insecticide-treated  net (LN) containing the active ingredient chlorfenapyr in combination with alpha-cypermethrin. Chlorfenapyr is new to vector control and is the first non-pyrethroid adulticide employed on an LN. Due to its new mode of action, chlorfenapyr shows no cross resistance to other insecticide classes.
BASF Product Information

Interceptor®

BASF Product Leaflet Interceptor® G2
BASF Product Leaflet

Interceptor® G2

BASF Editorial 'Beating the threat of increasing insecticide resistance
BASF Editorial

Beating the threat of increasing insecticide resistance

Scientific Research Papers And Field Trial Reports On Interceptor® G2