Chlorfenapyr – A New Approach

Long-lasting insecticide-treated mosquito nets and indoor residual sprays are the cornerstones of malaria prevention, particularly in sub-Saharan Africa. But 60 countries have already reported resistance to at least one class of insecticide used in them.

Part of the problem is that there were previously only four insecticide classes used for adult mosquito control: Only one of them, the pyrethroid class, was used on long-lasting insecticide treated nets. Continual use of the same insecticides enabled the highly-adaptable mosquito to develop significant levels of resistance. Alternatives are urgently needed.


Chlorfenapyr is a completely new insecticide class to combat mosquitoes in public health. It belongs to the pyrrole class of chemistry and has an entirely different mode of action to other insecticides used for vector control. It works by disrupting the insect’s ability to produce energy. This makes it unlikely to show cross-resistance in mosquitoes that are resistant to currently registered public health insecticides.


Chlorfenapyr was derived by isolating a toxin from the Streptomyces fumanus actinomycete bacterium. Although it is new to the public health market, it has been used in agriculture and urban pest control, including in homes and food handling areas, worldwide since 1995.


But exactly how does chlorfenapyr work? Watch our video:


Proven In Independent Trials

Independent trials in Benin, Burkina Faso, Tanzania and Ivory Coast have proven the efficacy of BASF's new chlorfenapyr products against local insecticide-resistant mosquitoes. Field trial results from the Innovative Vector Control Consortium show that BASF’s innovative chlorfenapyr-based, long-lasting mosquito net, Interceptor® G2, controls insecticide-resistant mosquitoes effectively. The development marks a significant scientific breakthrough that can meet the challenge of malaria control in areas where conventional nets are failing due to resistance.

BASF Product Leaflet Interceptor® G2

BASF Product Interceptor® G2

BASF Editorial 'Beating the threat of increasing insecticide resistance
BASF editorial

Beating the threat of increasing insecticide resistance