Agriculture

Publications

BASF is a worldwide leader in manufacturing the highest quality insecticide and larvicide products, but there are many further experts around the world discussing and researching the complex challenges of global public health.

Here is a selection of BASF publications, together with research papers, reports and articles from scientists, non-governmental organizations and the media - all involved in the quest to improve worldwide public health.

BASF Publications

BASF Editorial – 'Boosting The Battle Against Malaria – New Nets Project' (2019)

BASF Product Brochure Interceptor^® G2

BASF Product Leaflet - Interceptor^® G2

BASF Editorial - 'Beating The Threat Of Insecticide Resistance' (2016)

BASF Product User Guide - Abate^®

BASF User Guide - Abate 500^® E In Malaysia

BASF Product Brochure - Interceptor^®

BASF 'Creating Chemistry' - Malaria

BASF 'Creating Chemistry' - Neglected Tropical Diseases

BASF Editorial - 'From The Simple To The Sublime'

BASF Brochure - Public Health

BASF Poster - "Dengue Warriors"

External Publications

IVCC - 2024

New Nets Prevent 13 Million Malaria Cases in Sub-Saharan Africa (2024)

GatesNotes – The Insider Edition

Guinea worm – Only 13 people infected in 2023

The world is close to eradicating Guinea worm disease, a debilitating and painful condition that once devastated an estimated 3.5 million people in Africa and South Asia every year. Thanks to heroes like Makoy Samuel Yibi, that number dropped to 13 people in 2023.

MedAccess

A message from our CEO Michael Anderson

World Health Organization

WHO Guidelines for malaria 2023

Unitaid - hosted partnership of the World Health Organization

New classes of long-lasting insecticidal nets (LLINs) combining mixtures of insecticides with different modes of action could put malaria control back on track after rebounds in transmission across sub-Saharan Africa.

Bill & Melinda Gates Foundation

Why the Interceptor G2 net could be a game changer for malaria eradication

World Health Organization

New frontiers in vector control

World Health Organization

World Malaria Report 2021

The Carter Center

Guinea Worm Wrap-Up

Scientific Papers and Articles - Vector Control

The Lancet - January 24, 2023

Bed nets treated with new insecticide combinations reduced malaria infections by nearly half among children in Benin, according to new study.

MDPI, Insects - June 21, 2022

Modified World Health Organization (WHO) Tunnel Test for Higher Throughput Evaluation of Insecticide-Treated Nets (ITNs) Considering the Effect of Alternative Hosts, Exposure Time, and Mosquito Density (Dismas S. Kamande, Olukayode G. Odufuwa, Emmanuel Mbuba , Lorenz Hofer, and Sarah J. Moore)

The Lancet - Vol 399 / 10331 - March 26, 2022

Effectiveness and cost-effectiveness against malaria of three types of dual-active-ingredient long lasting-insecticidal nets (LLINs) compared with pyrethroid-only LLINs in Tanzania.

BMJ - Open Protocol, March 2021

Open Protocol for a four parallel-arm, single blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide[1]resistant vector mosquitoes in Tanzania.

BMC - Study Protocol, 2021

Durability of three types of dual active ingredient long-lasting insecticidal net compared to a pyrethroid-only LLIN in Tanzania: methodology for a prospective cohort study nested in a cluster randomized controlled trial.

Malaria Journal - Methodology, March 2022

Assessing the efficacy of two dual-active ingredients long-lasting insecticidal nets for the control of malaria transmitted by pyrethroid-resistant vectors in Benin: study protocol for a three-arm, single-blinded, parallel, cluster-randomized controlled trial (BMC infectious diseases).

Ummi Kibondo - Parasites & Vectors, 2022

Influence of testing modality on bio-efficacy for the evaluation of Interceptor^® G2 mosquito nets to combat malaria mosquitoes in Tanzania.

Malaria Journal - Vol. 20 / 180 - April 2021

Efficacy of interceptor^® G2, a long‑lasting insecticide mixture net treated with chlorfenapyr and alpha‑cypermethrin against Anopheles funestus: experimental hut trials in north‑eastern Tanzania: Patrick K. Tungu, Elisante Michael, Wema Sudi, William W. Kisinza and Mark Rowland.

Malaria Journal - Vol. 19 / 249 - July 2020

Indoor spraying with chlorfenapyr (a pyrrole insecticide) provides residual control of pyrethroid‑resistant malaria vectors in southern Benin: Corine Ngufor, Augustin Fongnikin, Neil Hobbs, Martial Gbegbo, Laurette Kiki, Abibath Odjo, Martin Akogbeto and Mark Rowland.

Parasites And Vectors - Vol. 13 / 239 - May 2020

Anopheles gambiae (s.l.) exhibit high intensity pyrethroid resistance throughout Southern and Central Mali (2016–2018): PBO or next generation LLINs may provide greater control: Arthur Sovi, Chitan Keita, Youssouf Sinaba, Abdourhamane Dicko, Ibrahim Traore, Moussa B. M. Cisse, Ousmane Koita, Dereje Dengela, Cecilia Flatley, Elie Bankineza, Jules Mihigo, Allison Belemvire, Jenny Carlson, Christen Fornadel, and Richard M. Oxborough.

Malaria Journal - Vol. 18 / 243 - July 2019

Diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against Anopheles malaria vector populations of western Kenya: Silas Agumba, John E. Gimnig, Lilian Ogonda, Maurice Ombok, Jackline Kosgei, Stephen Munga, Benard Guyah, Seline Omondi and Eric Ochomo.

Malaria Journal - Vol. 18 / 49 - February 2019

Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross‑resistance to other public health insecticides in Anopheles arabiensis from Ethiopia: Kendra Dagg, Seth Irish, Ryan E. Wiegand, Josephat Shililu, Delenasaw Yewhalaw and Louisa A. Messenger.

Parasite Journal - Vol. 25, August 8, 2018

Efficacy of Interceptor^® G2, a new long-lasting insecticidal net against wild pyrethroid-resistant Anopheles gambiae s.s. from Côte d’Ivoire: a semi-field trial: Soromane Camara, Ludovic Phamien Ahoua Alou, Alphonsine Amanan Koffi, Yao Cyntia Muriel Clegban, Jean-Paul Kabran, Fernand Mathieu Koffi, Kouakou Koffi and Cédric Pennetier.

Malaria Journal - Vol. 16, 2017

Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso: Koama Bayili, Severin N’do, Moussa Namountougou, Roger Sanou, Abdoulaye Ouattara, Roch K. Dabiré, Anicet G. Ouédraogo, David Malone and Abdoulaye Diabaté.

PlosOne - November 2016

A Chlorfenapyr Mixture Net Interceptor^® G2 Shows High Efficacy and Wash Durability against Resistant Mosquitoes in West Africa: Raphael N’Guessan, Abibatou Odjo, Corine Ngufor, David Malone, Mark Rowland

Trends In Parasitology - Vol 32, March 2016

Insecticide Resistance in African Anopheles Mosquitoes: A Worsening
Situation that Needs Urgent Action to Maintain Malaria Control.
H. Ranson, N. Lissenden

Malaria Journal - Vol 14, 2015

The activity of the pyrrole insecticide chlorfenapyr in mosquito bioassay: towards a more rational testing and screening of non-neurotoxic insecticides for malaria vector control. R.M. Oxborough, R. N’Guessan, R. Jones, J. Kitau, C. Ngufor, D. Malone, F.W. Mosha, M.W. Rowland.

PlosOne - Vol 9 (2), 2014

Mosquito nets treated with a mixture of the insecticides chlorfenapyr and alphacypermethrin control pyrethroid resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in West Africa. R. N'Guessan, C. Ngufor, A. Kudom, P. Boko, A. Odjo, D. Malone, M.W. Rowland.

PlosOne - Vol 8, 2013

ITN mixtures of chlorfenapyr (pyrrole) and alphacypermethrin (pyrethroid) for improved control of pyrethroid resistant Anopheles arabiensis and Culex quinquefasciatus. R.M. Oxborough, J. Kitau, J. Matowo, E. Feston, R. Mndeme, F.W. Mosha, M.W. Rowland.

American Journal Of Tropical Medicine And Hygiene - Overview

The American Journal of Tropical Medicine and Hygiene is the official scientific journal of the American Society of Tropical Medicine and Hygiene (ASTMH). The Society is a nonprofit, professional organization whose mission is to promote world health by the prevention and control of tropical disease through research and education.

Acta Tropica - Vol 118, 2011

Evaluation of the pyrrole insecticide chlorfenapyr for the control of Culex quinquefasciatus Say. K. Raghavendraa,∗, T.K. Barika, R.M. Bhattb, H.C. Srivastavac, U. Sreeharia, A.P. Dash.

Malaria Journal - Vol 10, 2011

Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. K. Raghavendra, T.K. Barik, P. Sharma, R.M. Bhatt, H.C. Srivastava, U. Sreehari, A.P. Dash.

Malaria Journal - Vol 10, 2011

Combining indoor residual spraying with chlorfenapyr and long-lasting insecticidal bed nets for improved control of pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Benin. C. Ngufor, R. N’Guessan, P. Boko, A. Odjo, E. Vigninou, A. Asidi, M. Akogbeto, M.W. Rowland.

Malaria Consortium, December 2010

Long-term insecticide activity of Interceptor® - a long-lasting insecticidal mosquito net, under field conditions in Western Uganda. Kilian, Byamukama, Pigeon, Gimnig, Atieli, Koekemoer, Protopopoff.

Acta Tropica, October 2010

Wash-resistance and field evaluation of alphacypermethrin treated long-lasting insecticidal net (Interceptor^®) against malaria vectors Anopheles culicifacies and Anopheles fluviatilis in a tribal area of Orissa, India. Sharma, Upadhyay, Haque, Tyagi, Raghavendra, Dash.

Transactions Of The Royal Society Of Tropical Medicine And Hygiene, April 2010

Wash resistance and residual efficacy of long-lasting polyester netting coated with alphacypermethrin (Interceptor^®) against malaria-transmitting mosquitoes in Assam, northeast India. Dev, Raghavendra, Singh, Phookan, Dash.

Tropical Medicine And International Health - Vol 15 (1), 2010

Evaluation of the pyrrole insecticide chlorfenapyr againstpyrethroid resistant and susceptible Anopheles funestus(Diptera: Culicidae). S.V. Oliver, M.L. Kaiser, O.R. Wood, M. Coetzee, M. Rowland, B.D. Brooke.

Transactions Of The Royal Society Of Tropical Medicine And Hygiene - Vol 104, 2010

Evaluation of indoor residual spraying with the pyrrole insecticidechlorfenapyr against pyrethroid-susceptible Anopheles arabiensis andpyrethroid-resistant Culex quinquefasciatus mosquitoes. R.M. Oxborough, J. Kitau, J. Matowo, R. Mndemea, E. Feston, P. Boko,A. Odjo, C.G. Metonnou, S. Irish , R. N’Guessan, F.W. Mosha, M.W. Rowland.

Malaria Journal - 2010

Evaluation of Interceptor long-lasting insecticidal nets in eight communities in Liberia. K. Banek, A.Kilian, R Allan.

Tropical Medicine And International Health - Vol 14, 2009

Control of pyrethroid-resistant Anopheles gambiae and Culexquinquefasciatus mosquitoes with chlorfenapyr in Benin. R. N’Guessan, P. Boko, A. Odjo, B. Knols, M. Akogbeto, M.W. Rowland.

Tropical Medicine And International Health - Vol 13, 2008

Experimental hut evaluation of the pyrrole insecticidechlorfenapyr on bed nets for the control of Anophelesarabiensis and Culex quinquefasciatus. F. W. Mosha, I. N. Lyimo, R. M. Oxborough, R. Malima, F. Tenu, J. Matowo, E. Feston, R. Mndeme,S. M. Magesa, M.W. Rowland.

Acta Tropica - Vol 102, 2007

Chlorfenapyr: A pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes. R. N’Guessan, P. Boko, A. Odjo, M. Akogbéto, A. Yates, M.W. Rowland.

Scientific Papers and Articles – Antimalarials (supported by BASF/Dr Matthias Witschel)

Helvetica Chimica Acta 2019, 102 (3)

Inhibitors of the Bifunctional 2-C-Methyl-D-erythritol 4-Phosphate Cytidylyl Transferase/2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate Synthase (IspDF) of Helicobacter pylori (based on BASF antimalarial leads). By Annika Honold; Clara Lettl; Franziska Schindele; Boris Illarionov; Rainer Haas; Matthias Witschel; Adelbert Bacher; Markus Fischer.

Nature Communications – 2018, 9 (1)

Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer (based on BASF antimalarial leads). By Scherr N; Bieri R; Thomas SS; Chauffour A; Kalia NP; Schneide P; Ruf MT; Lamelas A; Manimekalai MSS; Grüber G; Ishii N; Suzuki K; Tanner M; Moraski GC; Miller MJ; Witschel M, Jarlier V, Pluschke G, Pethe K.

Lancet Infectious Diseases – Feb 5, 2018

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. By Dicko, Alassane; Roh, Michelle E.; Diawara, Halimatou; Mahamar, Almahamoudou; Soumare, Harouna M.; Lanke, Kjerstin; Bradley, John; Sanogo, Koualy; Kone, Daouda T.; Diarra, Kalifa; et al

Malaria Journal - 2018, 17(1)

Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium. By Bosson-Vanga Henriette; Franetich Jean-Francois; Soulard Valerie; Sossau Daniel; Tefit Maurel; Silvie Olivier;Mazier Dominique; Bosson-Vanga Henriette; Sossau Daniel; Kane Bocar; et al

ChemMedChem – April 14, 2018

Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold: By Schwertz, Geoffrey; Witschel, Matthias C.; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit;Jaruwat, Aritsara; Amornwatcharapong, Watcharee; Ittarat, Wanwipa; Schaefer, Anja; Aponte, Raphael A.; et al

BMC Medicine - 2018, 16 (59)

Efficacy and safety of methylene blue in the treatment of malaria - a systematic review: By G. Lu, M. Nagbanshi, N. Goldau, M. Mendes Jorge, P. Meissner, A. Jahn, F. P. Mockenhaupt and O. Müller

Journal Of Medicinal Chemistry – 2017, 60 (12)

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures: By Schwertz, Geoffrey; Witschel, Matthias C.; Rottmann, Matthias; Bonnert, Roger; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Ittarat, Wanwipa; Schafer, Anja; Aponte, Raphael A.; et al

Chemistry - A European Journal - 2017, 23(57)

Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs: By Schwertz, Geoffrey; Frei, Michelle S.; Witschel, Matthias C.; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Ittarat, Wanwipa; Schaefer, Anja; Aponte, Raphael A.; et al

ACS Chemical Biology - 2017, 12(8)

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands: By Schwab, Anatol; Illarionov, Boris; Frank, Annika; Kunfermann, Andrea; Seet, Michael; Bacher, Adelbert; Witschel, Matthias C.; Fischer, Markus; Groll, Michael; Diederich, Francois

Nanoscale - 2016, 8(31)

An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery.  By Najer, Adrian; Wu, Dalin; Nussbaumer, Martin G.; Schwertz, Geoffrey; Schwab, Anatol; Witschel, Matthias C.; Schafer, Anja; Diederich, Francois; Rottmann, Matthias; Palivan, Cornelia G.; et al

ChemMedChem - 2015, 10(12)

Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum. By Thelemann, Jonas; Illarionov, Boris; Barylyuk, Konstantin; Geist, Julie; Kirchmair, Johannes; Schneider, Petra; Anthore, Lucile; Root, Katharina; Trapp, Nils; Bacher, Adelbert; et al

Journal Of Medicinal Chemistry - 2015, 58(7)

Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities. By Witschel, Matthias C.; Rottmann, Matthias; Schwab, Anatol; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Seet, Michael; Tonazzi, Sandro; Schwertz, Geoffrey; Stelzer, Frank; Mietzner, Thomas; et al

13th IUPAC International Congress Of Pesticide Chemistry, San Francisco – August 2014

Leads from Crop Protection against Neglected Diseases. By Matthias C Witschel.

Angewandte Chemie, International Edition - 2014

Deorphaning Pyrrolopyrazines as Potent Multi-Target Antimalarial Agents. By Reker, Daniel; Seet, Michael; Pillong, Max; Koch, Christian P.; Schneider, Petra; Witschel, Matthias C.; Rottmann,Matthias; Freymond, Celine; Brun, Reto; Schweizer, Bernd; et al

Angewandte Chemie, International Edition - 2014

Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD. By Kunfermann, Andrea; Witschel, Matthias; Illarionov, Boris; Martin, Rene; Rottmann, Matthias; Hoeffken, H. Wolfgang; Seet, Michael; Eisenreich, Wolfgang; Knoelker, Hans-Joachim; Fischer, Markus; et al

PLoS One - 2014, 9(7)

Novel bioassay for the discovery of inhibitors of the 2-C-methyl-d-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis. By Corniani, Natalia; Velini, Edivaldo D.; Silva, Ferdinando M. L.; Nanayakkara, N. P. Dhammika; Witschel, Matthias; Dayan, Franck E.

PLoS Neglected Tropical Diseases - 2012, 6(10)

Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. By Witschel Matthias; Rottmann Matthias; Kaiser Marcel; Brun Reto

ChemMedChem - 2012, 7(1)

Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates. By Mombelli, Paolo; Witschel, Matthias C.; van Zijl, Anthoni W.; Geist, Julie G.; Rottmann, Matthias; Freymond, Celine; Roehl, Franz; Kaiser, Marcel; Illarionova, Victoria; Fischer, Markus; et al

Antimicrobial Agents And Chemotherapy – 2012

Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans. By Scherr, Nicole; Roltgen, Katharina; Witschel, Matthias; Pluschke, Gerd

External Press Articles

Here's How To Wipe Malaria Off The Map - The Guardian, 14 July 2015

The malaria community has published a new vision and a concrete plan to reduce malaria mortality by 90 %. Dr. Pedro Alonso, Director, WHO Global Malaria Programme says, “We must accelerate progress toward malaria elimination to ensure that neither parasite resistance to drugs, mosquito resistance to insecticides, nor malaria resurgence unravels the tremendous gains to date.

Guinea Worm Almost Gone - Carter Center Press Release, 12 January 2015

The Carter Center announced today that only 126 Guinea worm cases were reported worldwide in 2014. These provisional numbers show that cases of the debilitating disease were reduced by 15 % in 2014 compared to 148 cases in 2013.

Combating Malaria - Financial Times, 25 April 2014

Researchers warn victory remains a long way off.

Makers Call For Overhaul Of Regime For Bed Net Sales - Financial Times (p3), 25 April 2012

Manufacturers of generic copies face less rigorous standards on the way to market, reports Andrew Jack.

Mosquitoes Are Target In Battle To Beat The Scourge - Financial Times, 25 April 2012

The carriers are at the centre of initiatives to tackle the illness, reports Clive Cookson.

Net Gains In The Malaria War - guardian.co.uk, 23 November 2011

A key weapon to combat 300,000 child deaths from malaria each year in Nigeria is long-lasting insecticidal nets. Finalist in The Guardian International Development Journalism competition, Charlotte Jenner investigates.

Researchers Probe Creative Ways To Kill Mosquitoes - Financial Times, 21 April 2011

Combating Malaria - Clive Cookson discusses the rapid evolution of resistance and the urgent need for replacement compounds.

The President And The Nematode - Der Spiegel, 13 December 2010

Nobel Peace Prize laureate Jimmy Carter is leading a unique battle to eradicate the Guinea worm. His efforts have brought the painful infection, transmitted via contaminated water, to the brink of elimination.

Eradicating Guinea Worm - The Lancet, 18 September 2010

The drive to eradicate Guinea worm or dracunculiasis from the planet is one of today's great but unrecognized public health successes.

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There are more than 200 million cases of malaria each year and almost half a million deaths. Infants, children under five and pregnant women are the most vulnerable groups.
Photo â Lassen/BASF
,There are more than 200 million cases of malaria each year and almost half a million deaths. Infants, children under five and pregnant women are the most vulnerable groups.
Photo – Lassen/BASF

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