BASF has received a historic recommendation from the World Health Organization for Interceptor® G2, a long-lasting insecticide-treated mosquito net to combat insecticide resistance. This is the first WHO recommendation for a product based on a new insecticide class in more than 30 years.
Interceptor® G2 – breakthrough to beat insecticide resistance
Working with the Innovative Vector Control Consortium and the London School of Hygiene & Tropical Medicine in a collaboration lasting more than a decade, BASF’s scientists successfully repurposed chlorfenapyr to be effective on mosquito nets and meet stringent WHO performance thresholds for public health. Chlorfenapyr is a completely new insecticide class for public health and Interceptor® G2 is the first bed net to contain non-pyrethroid chemistry. There hasn't been a WHO recommendation for a product based on a new class of insecticide since the 1980s.
Malaria is preventable and curable. Since 2010, nearly seven million lives, primarily young children, have been saved largely due to the distritubution of insecticide- treated mosquito nets. However, growing resistance to public health insecticides could threaten the progress of recent years. Alternatives like chlorfenapyr are urgently needed.
A second chlorfenapyr product, an indoor residual spray named Sylando® 240SC to coat walls and ceilings of homes, is also in the final phases of WHO evaluation.
The story behind the development
"A new development that actually enables the malaria community to deal with resistant mosquitoes - the first new mode of action product since 30 years in this market"
The scientists and developers behind Interceptor® G2 talk about the challenges, the highs and lows, and what this breakthrough in malaria control means to them personally.
Chlorfenapyr – a new approach
Long-lasting insecticide-treated mosquito nets and indoor residual sprays are the cornerstones of malaria prevention, particularly in sub-Saharan Africa. But 60 countries have already reported resistance to at least one class of insecticide used in them.
Part of the problem is that there were previously only four WHO-recommended insecticide classes for adult mosquito control: Only one of them, the pyrethroid class, was recommended for long-lasting insecticide treated nets. Continual use of the same insecticides enabled the highly-adaptable mosquito to develop significant levels of resistance.
Interceptor® G2, is now the first WHO-recommended mosquito net to contain non-pyrethroid chemistry. Based on a novel combination of chlorfenapyr, a pyrrole insecticide and alpha-cypermethrin, it both protects sleepers and combats insecticide-resistant mosquitoes.
Following the WHO recommendation, BASF will start preparations to launch Interceptor® G2. Depending on local registration processes, the new mosquito net is expected to be available to health ministries and aid organizations starting towards the end of this year.